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Some recent work aimed to develop tamoxifen analogues that can bypass CYP2D6 metabolism and use the esterase enzymes to produce the active metabolites to ensure equal clinical outcomes for all patients [66,67,68]

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A balanced reading of the literature is that ipamorelin and CJC-1295 reliably raise GH and IGF-1 in study settings, but the translation of those biomarker changes into durable, clinically meaningful outcomes in healthy adults remains insufficiently established