The nanoparticles improved MMP, reflected by an aggregate/monomer fluorescence ratio of 6.3 0.2 versus 3.7 0.2 in untreated, 1-methyl-4-phenylpyridinium (MPP+)-damaged cells (MPP is a neurotoxic compound causing mitochondrial dysfunction and neuronal cell death)
10.1016/j.nbd.2011.03.003 173 WegnerM
If side effects persist or worsen, it usually indicates a need for dose adjustment rather than discontinuation
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Reference - Jardiance Canada product monograph
Monitoring and follow-up should continue as recommended for tirzepatide therapy, typically including assessment of glycemic control (A1C), weight, gastrointestinal tolerability, and screening for potential adverse effects