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As the RIPK1-targeted inhibitor of necroptosis, necrostatin-1 could both rescue the ferroptosis and necroptosis of RPE cells via inhibiting RIPK1/RIPK3 activation and lipid ROS accumulation ( 3.5 Neuroprotective agent Acetyl5methoxytryptamine, also known as melatonin (C13H16N2O2), is a hormone that is secreted by the pineal gland in the brain, and shows great potential as a neuroprotective agent ( 4 Challenges for the application of ferroptosis targeting agents 4.1 Approved ferroptosis targeting agents Given the novel role of ferroptosis in the pathogenesis of various retinal diseases, ferroptosis is a promising therapeutic target
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Disease-modifying medications control major flares, but baseline joint stiffness and pain persist, particularly in the hands and wrists
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