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242 Additionally, UNA modification at the siRNA terminus improves siRNA stability and silencing efficacy while considerably reducing off-target effects, highlighting its potential in the development of new therapeutic siRNAs

IGF-1 LR3: mechanism and evidence base IGF-1 LR3 (insulin-like growth factor 1 long arginine 3) is an 83-amino-acid synthetic analogue of human IGF-1 in which glutamic acid at position 3 is replaced with arginine and an additional 13-amino-acid extension is appended to the N-terminus

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