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However, many studies and meta-analyses suggested that individuals with NAFLD experienced significant risks for subclinical and clinical cardiovascular events, even after adjustment for atherosclerotic cardiovascular disease (ASCVD) risk factor covariates, establishing ASCVD together with extrahepatic malignancies (mostly gastrointestinal and thyroid) as the leading causes of morbidity and mortality in individuals with less advanced disease [1315]
Results clearly showed that the c-met-binding of LASSS-treated HGF ( blue bars 4 ) was more than double that of the control level of HGF ( gray bars 3 , with the wash-out step)
Rights and permissions About this article Cite this article Mudaliar, S., Henry, R.R
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10.1038/sj.onc.1209267 36 CroceL.RuggeriR
However, in another study using an INS-1 832/3 cell line, the metformin-induced upregulation of GLP-1R mRNA expression was mediated via peroxisome proliferator-activated receptor- rather than AMPK pathway 30
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