Shifting CrAT activity towards the production of acetylcarnitine may rescue beta-oxidation by increasing free CoA, but it only partially solves problems of energy deficiency because the acetyl groups do not enter the Krebs cycle for energy production, but rather escape from the mitochondria in the form of acetylcarnitine
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The negative effects seem minimal. Babak Firoozi, MD MNT also spoke with Seth Kipnis, MD, FACS, FASMBS, medical director of Bariatric and Robotic Surgery at Hackensack Meridian Jersey Shore University Medical Center in New Jersey, about this research
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doi: 10.1096/fj.202300198RRR 154 DuBDengZChenKYangZWeiJZhouLet al
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