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Studies have shown that tamoxifen resistance is associated with IGFBP-1 accumulation and that the overexpression of IGFBP-1 promotes tamoxifen resistance in breast cancer cells by activating the ERK pathway, which can be reversed by knocking down IGFBP-1 (134)

Abbreviations AMH: Anti-mllerian hormone ART: Assisted reproductive technology COS: Controlled ovarian stimulation DHEAS: Dehydroepiandrosterone sulphate ECLIA: Electrochemiluminescence immunoassay ELISA: Enzyme-linked immunosorbent assay FET: Frozen embryo transfer FBS: Fasting blood sugar GnRH: Gonadotropin-releasing hormone HCG: Human chorionic gonadotropin HDL: High-density lipoprotein IVF/ICSI: in vitro fertilization/intracytoplasmic sperm injection LDL: Low-density lipoprotein LH: Luteinizing hormone OHSS: Ovarian hyperstimulation syndrome PCOS: Polycystic ovarian syndrome rFSH: Recombinant follicle stimulating hormone SD: Standard deviation References Webb K

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This PBS attachment gives a granular appearance between TMs

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Engineered cells and EVs may allow more precise delivery of microRNAs, antioxidant enzymes, mitochondrial regulators, or targeting ligands [27,28,29,30]