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Brainstem preproglucagon expressing fibers project to many areas of the brain with the most abundant projections to areas hypothalamic areas that control energy homeostasis including the arcuate nucleus (ARC), paraventricular nucleus (PVN), and dorsomedial nucleus (DMH) (Jin et al., 1988)
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The change in the BMP signaling gradient along the crypt-villi axis could induce hormone changes in EECs during the migration of these cells along the crypt-villus axis
However, when it undergoes the process of acetylation, which involves adding an acetyl group to a molecule, it has a greatly improved ability to cross the blood-brain barrier
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