Brighten: of McCall McPhereson: semaglutide
It activates GHS-R1a (the target receptor for GH release) but also cross-reacts with receptors that elevate adrenocorticotropic hormone (ACTH), cortisol, and prolactin
In animal models, it has been studied for its potential to protect the stomach lining from damage caused by toxins or NSAIDs and to help manage conditions like inflammatory bowel disease (IBD)
Benefits Improved skin elasticity Improved sleep quality Increased lean muscle mass, reduced body fat, and faster muscle recovery Improved insulin sensitivity Dosing Subcutaneous 200 mcg 500 mcg Once daily At bedtime 12 weeks ON
Yoon KH, Kang J, Kwon SC et al (2020) Pharmacokinetic and dose-finding studies on efpeglenatide in patients with type 2 diabetes
Creatine combined with semaglutide supports muscle preservation during weight loss