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This epigenetic alteration results in cancer progression, drug resistance [34], metastasis and stemness induction [35, 36], metabolic alterations by affecting enzymes involved in the tricarboxylic acid cycle (TCA), and carbohydrate, amino acid, fatty acid, and nucleotide metabolism [35], hence opening the way to the generation of novel therapeutic strategies against lysine lactylation, not only regarding histones (Fig

Finally, while pharmacological tolerance might be considered, there is no established evidence linking prolonged tirzepatide use with reduced efficacy

[19] Because of its antioxidant role, GSS mostly produce GSH inside the cytoplasm of liver cells and imported to mitochondria where detoxification occurs

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Very low sodium intake, which can happen unintentionally when appetite is suppressed and food intake drops, contributes to low blood pressure and the dizziness that goes with it

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