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One hypothesis is that GIP enhances energy expenditure through effects on brown adipose tissue and skeletal muscle metabolism

GR113808 reduced the size of adipocytes upon HFD feeding HFD feeding increased the size of lipid droplets, but GR113808 prevented this increase in WAT droplet size (Fig

Activation of IDO1 in DCs was linked to ARG1-dependent production of polyamines

This network enables intestinal states to modulate distal organ function while allowing distal organs to reciprocally influence gut physiology [74, 75]

[1] Receptor selectivity tuning : The arrangement of the amino acid sequence is designed to determine the relative agonist activity at each of the three receptors