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Different chemical scaffolds can generate different reactive metabolites, and the safety of one small-molecule GLP-1 agonist does not automatically predict the safety of another
Candidates generally have a BMI of 30 or higher, or a BMI of 27 with a weight-related condition such as type 2 diabetes, hypertension, elevated cholesterol, or sleep apnea
These effects are typically most pronounced during treatment initiation and dose escalation, often improving over several weeks
This can be very painful and usually needs medical care right away
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February 2018
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