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The production of quinone imine metabolite is the primary responsible for PAC liver and kidney toxicity

For those with thalassemia, the hematologist will consider a variety of treatment options based on the severity of the symptoms, such as blood transfusions, folic acid supplements, iron chelation, splenectomy, bone marrow transplant, or stem cell transplant, which is the only known curative treatment for thalassemia

F., Hsu, A., Werner, P., Perl, D

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