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When the ratio of NADP + /NADPH increases, G6PD becomes more active, and the reduction of NADP + to NADPH increases

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The PPP branches after the first step of glycolysis and consumes the intermediate glucose 6-phosphate (G6P) to generate fructose 6-phosphate (F6P) and glyceraldehyde 3-phosphate (G3P) through the oxidative and non-oxidative branches of the PPP

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doi: 10.3389/fimmu.2017.01239 Received 27 June 2017 Accepted 19 September 2017 Published 29 September 2017 Volume 8 - 2017 Edited by Anna Rubartelli, IRCCS AOU San Martino IST, Italy Reviewed by Cecilia Garlanda, Istituto Clinico Humanitas, Italy

V.San-MiguelJ.GoldschmidtH.SonneveldP.DimopoulosM