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Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1

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NADPH oxidase 4 (NOX4)-mediated oxidation of PTP1B in the endoplasmic reticulum enhances EGFR phosphorylation (89)

On the other hand, proline metabolism supports chimeric antigen receptor (CAR) T cells antitumor activity against breast cancer cells [104], and also the proinflammatory effects of macrophages, supporting trained immunity [105] (Table 4)