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Saxenda (liraglutide): Still covered for specialist Tier 3 services under NICE guidance (TA664), but rarely used now
Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years
Though these are a normal part of human metabolism, they cause significant oxidative stress over time, damaging DNA inside cells and leading to premature aging
Moreover, administering sesamol and pterostilbene can increase the levels of butyric acid, isobutyric acid, and valeric acid in DCI mice
Notably, the maximum reduction in A1C occurred by week 26, demonstrating sustained effectiveness throughout the trials
Dal Pozzo V, Benelli C, Restano L, Gianotti R, Cesana BM
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