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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
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Baseline laboratory studies should include electrolytes (sodium, potassium, magnesium), renal function, and hemoglobin A1c
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Immunogenicity testing follows a tiered approach: ECL or ELISA screening for ADA presence, competitive inhibition confirmatory assay, and cell-based neutralization assay for NAb characterization
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