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IGF is mainly produced by the liver, as well as tumor cells and cancer-associated macrophages (Fig
Patients with pre-existing gastroparesis, significant gastrointestinal disease, or previous gastric surgery require particularly careful monitoring and may benefit from gastroenterology consultation before initiating GLP-1 agonist therapy
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doi:10.1056/NEJM200004273421716
doi: 10.1186/s12933-025-02649-0
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