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This article was financially supported by National Institutes of Health Public Health Service grants R01 HL144790, R01 HL151493, R01 AI145813, R01 AI169687, R01 HL151769, and R01 HL159804 (OA)

Who might benefit from each

The standard escalation protocol is designed to minimize gastrointestinal side effects while achieving therapeutic doses

Fitness trackers can give you insights into your steps and active minutes, while progress photos can highlight shifts in body composition that numbers alone might miss

This multifaceted role shows the physiological significance of melatonin as a mitochondrial antioxidant, a notion supported by numerous scholars

38,39 A MAI Calculator is available at no cost for use here: HOW TO SAFELY DEPRESCRIBE Deprescribing Tools Once polypharmacy and PIMs are identified, many clinical tools are available to analyze benefit versus risk and guide pharmacy teams on how to safely discontinue specific medications and medication classes