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In the study by Neelakantan et al

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GSH depletion strategies have improved PDT and SDT by incorporating metals like Cu and Mn to amplify ROS and sensitize tumors [78]

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This less conserved domain, compared to the N-terminal domain, notably contains a well-conserved N-capping box (S/TXXD) including the S/T N-cap residue (Figure 3A) and a hydrophobic staple motif located at the N-terminal part of 6 helix

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Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications

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