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doi:10.1007/s11427-017-9272-2
Epidemiologic studies report associations between circulating osteocalcin levels and markers of metabolic health, including glucose tolerance and insulin sensitivity, but effect sizes vary and causality remains uncertain ( Rather than undermining osteocalcins relevance, these challenges highlight the need for standardized assays, context-aware study designs, and pharmacologic tools that directly modulate osteocalcin signaling
Then, as proposed above, inflammaging can also be involved in aged cell/tissue processes in younger individuals
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