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Upon FGF15/FGF19 is secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/beta-klotho heterodimer complex, triggering JNK1/2 and ERK1/2 signaling cascades, leading to the inhibition of CYP7A1 expression (Potthoff et al., 2012)

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& Hussain, S

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It belongs to a novel class of agents known as triple hormone receptor agonists, meaning it simultaneously targets three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

Without adequate Se, there is an imbalance between the activation and inactivation of thyroid hormones [47]