Dosis en estudios animales: En la gran mayora de los estudios preclnicos, las dosis utilizadas en la rata se sitan entre 10 g/kg y 10 ng/kg de peso corporal, administradas por va intraperitoneal u oral
That is the largest weight loss ever recorded in a GLP-1 class drug trial
On the basis of this pharmacokinetic difference, in the ongoing phase 3 clinical trial programme for IcoSema, an initial dose of IcoSema corresponding to 0.114 mg semaglutide has been selected, hence lower than the 0.25 mg recommended as starting dose for semaglutide alone [25,26,27]
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