In toxin-induced PD mouse models, DA-JC1, a novel dual GLP-1/GIP receptor agonist, improved motor impairment, increased the number of dopaminergic neurons in the substantia nigra, enhanced BDNF levels, and modulated apoptosis signaling pathways by altering the expression of Bax and Bcl-2 [89, 90]
Diabetes 1994
Dispose of the needle in a sharps container immediately
This is such an important reminder: GLP-1 therapy can shift physiology, but it cannot replace the foundational habits that protect metabolic health
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Nov 2019;64(11):747-760