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We conclude from these studies that the insulinotropic effects of tirzepatide are mediated by both receptors, but that the contribution of each receptor varied from donor to donor
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While these conjugates are experimental, they demonstrate the power of co-activating both pathways simultaneously
The GLP-2 (333), a biologically inactive form of GLP-2, which is a product of degradation of N-terminus of GLP-2 (133) by DPP-IV, may act as a weak partial agonist of the GLP-2 receptor in a negative feedback mechanism
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