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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

Using bacteriostatic (bac) water is normally recommended

Digivibe is a small, handheld device that uses gentle vibration to distract nerve endings during injection, making the process virtually painless

Getting used to the protocol

High-dose B12, given through injections, may help ease these symptoms

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