7.6 Reframing complexity as translational opportunity Collectively, the neuroendocrine and immunemetabolic peptide systems reviewed in this section challenge the assumption that therapeutic targets must be narrowly defined, peripherally restricted, and mechanistically simple
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36 , 865874 (2018) Vatine, G.D., Barrile, R., Workman, M.J., Sances, S., Barriga, B.K., Rahnama, M., Barthakur, S., Kasendra, M., Lucchesi, C., Kerns, J., Wen, N., Spivia, W.R., Chen, Z., Van Eyk, J., Svendsen, C.N.: Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications