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In the synovium, fibroblast-like synoviocytes and infiltrating immune cells secrete proinflammatory cytokines such as IL-1, IL-6, and TNF-
In situ metabolomics in nephrotoxicity of aristolochic acids based on air flow-assisted desorption electrospray ionization mass spectrometry imaging
Repetitive mTBI increases the risk for neurodegenerative diseases and accelerates the accumulation of pathological hallmarks in the brain 14
A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment
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It can cause bone and cartilage abnormalities in very young children
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