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Verdict: Fascinating research, but far from a proven anti-aging therapy

The review covered multiple studies demonstrating that activation of the angiotensin IV receptor (AT4/HGF/c-Met) system improves cognitive performance in animal models

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But the same disruption means the skin is more reactive to potential irritants in the formulation, including preservatives, fragrances, surfactants, and even some peptide stabilizers

Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

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