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Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms

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No toxic or lethal dose was achieved across a remarkably wide range of doses from 0.006 mg/kg to 20 mg/kg

Per the FDA, compounded drugs that contain DSIP may pose a risk for immunogenicity,26 a state in which the body perceives a substance as a threat and so mounts a potentially life-threatening immune response against it

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