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Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]
Chrysin reduces cyclin D1 accumulation, blocking Rb phosphorylation and halting G1/S transition (55)
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Be consistent, not excessive Visible improvement usually comes from regular use over time