Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling
The GLP-1 drugs are the latest class to show a benefit in patients, this time with OSA, but like other tools have nontrivial side effects, cost concerns, and patient persistence issues that balance out the headline benefits. The size of the underlying patient populations, which are expected to surpass 1.3 billion globally by 2050, as well as the under penetration of CPAP treatment, which Andrew ballparks at 15% or less in many markets, reinforces the analysts argument
In December, the FDA declared that tirzepatide, the other popular GLP-1 drug, was no longer in shortage
Dupre et al also studied the effects of GLP-1 on glucagon suppression by administering exenatide to patients with type-1 diabetes
This project was supported by a Stanford Medicine Discovery Innovation Award to Dr
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