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When your body faces a challenge, your immune cells undergo a burst of activity that creates oxidative byproducts

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Activation of fetal-like molecular programs during regeneration in the intestine and beyond

In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Cadenas and Davies, 2000)

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In vitro studies have also indicated that riboflavin itself has an antioxidant nature, independent of its action as the GR coenzyme ( Reference Toyosaki and Mineshita 47 )