In line with these observations, the nitrotyrosine level in the liver of hepsin / mice was approximately 2- to threefold higher than that measured for wild-type mice, with this difference becoming noticeable as early as 2 h post-APAP administration (Fig
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10.1164/ajrccm.165.4.2101124 16 BerthiaumeY.MatthayM
Two assays were prepared for each sample: one unstimulated to determine basal ROS production and one 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulated to induce an oxidative burst by NADPH-oxidase activity