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The uncontrolled generation of GSSG during oxidative stress can contribute to mitochondrial dysfunction by glutathionylation of target proteins, as described below

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Application Areas: Metabolic Disease Research: Obesity, insulin resistance, type 2 diabetes mechanism and drug development Aging and Longevity Research: NAD+ homeostasis, mitochondrial function, regulation of cell aging pathways Neuroscience Research: Exploration of protective effects on neurodegenerative diseases such as Parkinsons disease Sports Science: Enhancing endurance, promoting muscle repair and improving physical performance research

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Use cases for GLP-1 research powered by Truveta Data The below examples highlight some of the key use cases for studying GLP-1 data, all of which have already been enabled by Truveta Data: Comparative effectiveness of GLP-1 therapies: In the largest comparative effectiveness study to date on tirzepatide vs