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Once in circulation, IGF-1 LR3 binds to IGF-1 receptors (IGF-1R) located on muscle, bone, and connective tissues
10.1007/s10555-024-10192-9 32 IwamotoY.KimuraT.DanK.IwamotoH.SanadaJ.FushimiY.et al (2024)
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Given that both SGLT2i and GLP-1 RA demonstrate robust and consistent cardio-renal benefits [14], both agents seem to be an attractive option to fulfil an unmet therapeutic need in type 1 diabetes
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Ionescu-Tucker and Cotman, 2021)
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