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The answer is often both
doi.org/10.1016/j.chemgeo.2013.05.039
Consistent with other GLP-1 receptor agonists administered through subcutaneous injections, the most frequently recorded adverse events of oral semaglutide treatment were nausea and vomiting
This disorder arises from impaired lymphatic drainage due to either congenital abnormalities (primary lymphedema) or acquired damage to the lymphatic system (secondary lymphedema)
It should be noted that fibrotic regulation is a multi-layered process involving post-transcriptional control, extracellular matrix deposition, and tissue architecture, which are not fully captured by transcriptomic analyses alone
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