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67 In parallel, oncolytic viruses and personalized cancer vaccines are under active preclinical investigation to re-establish tumor antigenicity

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257,258 The Hippo pathway also modulates apoptosis, as MST1/2 signaling can activate proapoptotic programs, whereas oncogenic RAS, PI3K/AKT, and RAF signaling suppress MST2 activity and promote cancer cell survival

Current Pharmaceutical Design, 23(27), 4012-4028

Loading Phase Initial period of higher-frequency dosing designed to build tissue concentrations quickly