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Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77

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In summary: Sermorelin stimulates natural GH release (acting upstream), while hGH therapy provides external GH (acting downstream)

Secondly, IGF-1 has a strong effect on skeletal muscle In regards to the life span of satellite cells

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