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A peptide with reduced acidity was designed for increased cell permeability The p53 TAD2 sequence exhibited a highly negative charge, whereas the p53 binding interface of the FOXO4 FHD contains several positively charged residues
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Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
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Starting at high doses significantly increases nausea, vomiting, and gastrointestinal side effects that often lead to treatment discontinuation
Yet, alterations in EEC numbers and secretion of gut hormones have also been observed in intestinal inflammation and were implicated in the changes in feeding patterns often accompanying these conditions (146, 147) (Figure 4)
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