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Free copper is extremely reactive through Fenton chemistry, and it stimulates the secretion of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-4, and tumor necrosis factor (TNF) in both the brain and the blood (Tokuda et al., 2009)
25 As an endocrine hormone, GLP-1 is secreted by enteroendocrine L-cells in the distal jejunum, ileum, and colon in response to food intake and neuroendocrine signals
W.BakshiM.SherametiI.DongS
This novel dual-agonist approach surpassed the efficacy of monotherapy while maintaining a favorable costbenefit and safety profile [122]
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