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In the UK, NICE guidance (NG28) recommends considering GLP-1 receptor agonists for patients with type 2 diabetes according to specific criteria, typically when treatment with metformin and other oral medications has not achieved adequate glycaemic control

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If nausea is severe or accompanied by vomiting, medical advice should be sought to prevent dehydration and ensure proper management

This regulatory activity may support endothelial function and promote vessel relaxation, contributing to improved hemodynamic balance in experimental settings