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If it occurs, HIV-associated oral mucosal melanin hyperpigmentation usually develops within 2 years of contracting HIV or within a few months of starting antiretroviral treatment with the drug zidovudine

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And then not all the embryos will be viable

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Proc Natl Acad Sci USA 107(16):74557460 Ippolito L, Giannoni E, Chiarugi P, Parri M (2020) Mitochondrial redox hubs as promising targets for anticancer therapy