Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - an update of recent progress
In the context of these co-crystal structures, Compound 24 consistently engaged key conserved hydrophobic residues (M336, L388, F392, and F424) and formed hydrogen bonds with Q421, while additional interactions with H223, Y222, I371, H373, I428, P408, L409, M389, and V417 contributed to specificity (Figures 9AE)
Preliminary results suggest that GHK could be more proficient at neutralizing OH radicals compared to these alternatives
These are preclinical findings, not human clinical proofs
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