The SELECT trial was even larger, enrolling 17,604 patients with obesity and pre-existing cardiovascular disease but without diabetes
In fact, done thoughtfully, discussions of pharmacotherapy with patients can be openings for providers to further destigmatize obesity by helping patients to understand the multifactorial nature of their disease
When gut bacteria ferment fibre in the colon, they produce short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate, which directly stimulate GLP-1 release from intestinal L-cells
Long-Term Safety Data and Research Long-term safety data in humans remain limited
Kala, P
BDNF signaling is frequently downregulated in neurodegenerative conditions, and strategies to restore its levels have demonstrated improvements in synaptic integrity and cognitive outcomes [129, 130]