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Putrescine serves as an immediate precursor for the other two polyamines spermidine and spermine synthesis through receiving the aminopropyl from decarboxylated S-adenosylmethionine (dcAdoMet or decSAM) by spermidine synthase (SPDSY) and spermine synthase (SPMSY), successively (Figure 1)
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All animal studies were approved by the Augusta University Institutional Animal Care and Use Committee (#2019-1010)
A single peptide saturates one receptor system
Receptor for advanced glycosylation end products (RAGE)
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