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While this provides body composition benefits including fat loss and muscle growth, it also affects glucose metabolism (often elevating blood sugar), increases IGF-1 (with implications for cell proliferation), and costs significantly more than AOD-9604
Side effects are typically mild injection-site reactions, flushing, increased heart rate, nausea, headache
Clinical Considerations The evidence hierarchy clearly favors oral collagen peptides combined with resistance training over injectable peptides for muscle enhancement
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Always use gentle swirling motions instead
The total human evidence base, as of this writing, consists of the following: 1) a Phase I safety trial of 42 healthy volunteers that was registered in 2015, canceled in 2016, and never published, 2) a retrospective case series of 12 patients with knee pain, no control group, and no validated outcome measure, and 3) a 2025 pilot safety study involving two healthy adults who received intravenous infusions at a single private clinic in Florida
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