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( 6.3 Stratification by comorbidities 6.3.1 Comorbid cardiovascular or chronic kidney disease In patients with coexisting cardiovascular disease (such as heart failure) or chronic kidney disease (CKD stages G1G3), both remission efficacy and organ protection must be considered
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Moreover, these platforms frequently provide digital tools for tracking progress
Additionally, these metabolic interventions can potentially reverse the immunosuppressive phenotype of the TME, enhancing the efficacy of ICIs [77, 78]