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Arch Biochem Biophys 356:111 Keshavarzian A, Banan A, Farhadi A, Komanduri S, Mutlu E, Zhang Y, Fields JZ (2003) Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease
This reduction in metabolic heat production could potentially manifest as feeling colder than usual, especially in cooler environments
A patient who wants to relieve obstructive sleep apnea and eliminate their CPAP machine may require a 10% or 15% weight loss
Whether dehydration is related to GLP-1 side effects or simply not drinking enough, the warning signs tend to look very similar (9)
Brief exposure above this threshold (a few hours in a hot car) may not destroy the medication, but repeated or prolonged heat exposure reduces potency
Lower starting points (around 1 mg/day) are typical for new research planning, and 2 mg/day is the high end most references cite
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