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The tradeoff: nearly all data comes from rodent studies
Regulatory status changes from time to time
Hemoglobin A1c levels tend to rise within weeks to months after discontinuation, returning toward pre-treatment values
A later update will be required if the agency posts meeting minutes, an interim enforcement statement, a proposed rule, a final rule or another official decision affecting any of the seven substances
Santra M, Zhang ZG, Yang J, Santra S, Santra S, Chopp M, Morris DC
Weight regain upon discontinuation is common with all GLP-1 therapies: Clinical data consistently show that weight regain occurs when GLP-1 receptor agonists are discontinued, typically recovering 50-75% of lost weight within 1-2 years
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